Mirin | B1075

Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex. Mirin blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC₅₀ = 12 μM) and induces G2 cell cycle arrest.

Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex. Mirin blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC₅₀ = 12 μM) and induces G2 cell cycle arrest.

B1075 | Mirin DataSheet

Alternate Name/Synonyms: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 1198097-97-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₈N₂O₂S

Molecular Weight: 220.25

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex

MDL Number: N/A

PubChem CID: 1206243

SMILES: C1=CC(=CC=C1C=C2C(=O)N=C(S2)N)O

InChi: InChI=1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-

InChi Key: YBHQCJILTOVLHD-YVMONPNESA-N