Mitomycin C | 2713

Mitomycin C is an antitumor antibiotic isolated from Streptomyces sp. Mitomycin is activated by reduction in vivo generating oxygen radicals which produce crosslinks in DNA by alkylaion. This mechanism ultimately inhibits DNA synthesis which has a bacteriostatic effect. Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.

Mitomycin C is an antitumor antibiotic isolated from Streptomyces sp. Mitomycin is activated by reduction in vivo generating oxygen radicals which produce crosslinks in DNA by alkylaion. This mechanism ultimately inhibits DNA synthesis which has a bacteriostatic effect.

2713 | Mitomycin C DataSheet

Alternate Name/Synonyms: [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; Ametycine

Appearance: Bluish crystalline solid

Formulation: N/A

CAS Number: 50-07-7

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₈N₄O₅

Molecular Weight: 334.33

Cell-Permeable?: No

Purity: Potency: ≥970 µg/mg

Solubilities: DMSO (~15 mg/ml) or H₂O (~0.5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An antitumor antibiotic

MDL Number: MFCD00078109

PubChem CID: 5746

SMILES: CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N

InChi: InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

InChi Key: NWIBSHFKIJFRCO-WUDYKRTCSA-N