MK-0941 | B1207

MK-0941 is selective, allosteric glucokinase activator (GKA) that activates glucokinase (hexokinase subtype IV) with greater selectivity than over different hexokinase isoforms. MK-0941 shows decrease in mean fasting plasma glucose in healthy participants by 30 mg/dL. It displays greater effect in type 2 diabetic patients by lowering the fasting plasma glucose by 100 mg/dL.

MK-0941 is selective, allosteric glucokinase activator (GKA) that activates glucokinase (hexokinase subtype IV) with greater selectivity than over different hexokinase isoforms. MK-0941 shows decrease in mean fasting plasma glucose in healthy participants by 30 mg/dL. It displays greater effect in type 2 diabetic patients by lowering the fasting plasma glucose by 100 mg/dL.

B1207 | MK-0941 DataSheet

Alternate Name/Synonyms: 3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Appearance: Crystalline Solid

Formulation: N/A

CAS Number: 1137916-97-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₄N₄O₆S

Molecular Weight: 460.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(> 5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An allosteric glucokinase activator (GKA)

MDL Number:

PubChem CID: N/A

SMILES: O=C(NC1=NN(C)C=C1)C2=CC(O[C@@H](C)CO)=CC(OC3=CC=C(S(=O)(CC)=O)N=C3)=C2

InChi: InChI=1S/C21H24N4O6S/c1-4-32(28,29)20-6-5-16(12-22-20)31-18-10-15(9-17(11-18)30-14(2)13-26)21(27)23-19-7-8-25(3)24-19/h5-12,14,26H,4,13H2,1-3H3,(H,23,24,27)/t14-/m0/s1

InChi Key: KJSGTWFWVTYPFZ-AWEZNQCLSA-N