MK-1439 | B1250

MK-1439 (also known as Doravirine), is a non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT), K103N and Y181C reverse transcriptase (RT) mutants, respectively. It displays excellent activity of suppressing the replication of WT virus with 95% effective concentration of 20 nM. It also exhibited anti-virus activity against 10 different HIV-1 subtype viruses including K103N, Y81C.

MK-1439 (also known as Doravirine), is a non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS with IC₅₀ values of 12, 9.7, and 9.7 nM against the wild type (WT), K103N and Y181C reverse transcriptase (RT) mutants, respectively.

B1250 | MK-1439 DataSheet

Alternate Name/Synonyms: 3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile; Doravirine

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 1338225-97-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₁ClF₃N₅O₃

Molecular Weight: 425.75

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS

MDL Number:

PubChem CID: 58460047

SMILES: CN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F

InChi: InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28)

InChi Key: ZIAOVIPSKUPPQW-UHFFFAOYSA-N