MK-1775 | 2373

MK-1775 is a potent and selective inhibitor of the tyrosine kinase WEE1 (IC₅₀ = 5.2 nM). It selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.

MK-1775 is a potent and selective inhibitor of the tyrosine kinase WEE1 (IC₅₀ = 5.2 nM).

2373 | MK-1775 DataSheet

Alternate Name/Synonyms: 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 955365-80-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₂N₈O₂

Molecular Weight: 500.6

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~80 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A WEE 1 kinase inhibitor

MDL Number: N/A

PubChem CID: 24856436

SMILES: CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O

InChi: InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,

InChi Key: BKWJAKQVGHWELA-UHFFFAOYSA-N