MK-4827 | 9462

MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumour models with loss of BRCA and PTEN function.

MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumour models with loss of BRCA and PTEN function.

9462 | MK-4827 DataSheet

Alternate Name/Synonyms: 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide; Niraparib

Appearance: Light yellow solid

Formulation: N/A

CAS Number: 1038915-60-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₉H₂₀N₄O

Molecular Weight: 320.39

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>4 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective PARP-1 and PARP-2 inhibitor

MDL Number: N/A

PubChem CID: 24958200

SMILES: C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N

InChi: InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1

InChi Key: PCHKPVIQAHNQLW-CQSZACIVSA-N