MK-4827 (Tosylate) | B2003

MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumor models with loss of BRCA and PTEN function.

MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumor models with loss of BRCA and PTEN function.

B2003 | MK-4827 (Tosylate) DataSheet

Alternate Name/Synonyms: (3S)-3-[4-[7-(Aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidine Tosylate; MK-4827 Tosylate; Niraparib tosylate

Appearance: Off-white to pale yellow solid

Formulation: N/A

CAS Number: 1038915-73-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₀N₄O •C₇H₈O₃S

Molecular Weight: 492.6

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective PARP-1 and PARP-2 inhibitor

MDL Number: N/A

PubChem CID: 78357761

SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N

InChi: InChI=1S/C19H20N4O.C7H8O3S/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;1-6-2-4-7(5-3-6)11(8,9)10/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);2-5H,1H3,(H,8,9,10)/t14-;/m1./s1

InChi Key: LCPFHXWLJMNKNC-PFEQFJNWSA-N