MK-571 | 2691

MK 571 is a selective, CysLT1 receptor antagonist. It blocks the binding of leukotriene LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK 571 effectively blocks LTD4 activation of recombinant human and murine CysLT1 receptors but is ineffective at blocking LTC4 or LTD4activation of the recombinant human or murine CysLT2 receptors. MK-57 also acts as a specific inhibitor of multi-drug resistance protein-1 (MRP1).

MK-571 is a selective, CysLT1 receptor antagonist. It blocks the binding of leukotriene LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK 571 effectively blocks LTD4 activation of recombinant human and murine CysLT1 receptors but is ineffective at blocking LTC4 or LTD4activation of the recombinant human or murine CysLT2 receptors. MK-57 also acts as a specific inhibitor of multi-drug resistance protein-1 (MRP1).

2691 | MK-571 DataSheet

Alternate Name/Synonyms: (E)-​3-​[[[3-​[2-​(7-​chloro-​2-​quinolinyl)ethenyl]phenyl][[3-​(dimethylamino)-​3-​oxopropyl]thio]methyl]thio]-​propanoic acid; L-660,711

Appearance: Yellow solid

Formulation: N/A

CAS Number: 115104-28-4

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₇ClN₂O₃S₂

Molecular Weight: 515.09

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective, CysLT1 receptor antagonist and multi-drug resistance protein-1 (MRP1) inhibitor

MDL Number: N/A

PubChem CID: 5281888

SMILES: CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O

InChi: InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+

InChi Key: AXUZQJFHDNNPFG-UXBLZVDNSA-N