MK-591, Free acid | B2520

MK-0591 is a potent and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in FLAP binding assay; it displays no inhibitory effect on 15-lipoxygenase and platelet 12-lipoxygenase and cyclooxygenase in human PMNLs; potently inhibits leukotriene (LT) biosynthesis in intact human and elicited rat PMNLs with IC₅₀ of 3.1 and 6.1 nM, respectively.

MK-0591 is a potent and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in FLAP binding assay; it displays no inhibitory effect on 15-lipoxygenase and platelet 12-lipoxygenase and cyclooxygenase in human PMNLs; potently inhibits leukotriene (LT) biosynthesis in intact human and elicited rat PMNLs with IC₅₀ of 3.1 and 6.1 nM, respectively.

B2520 | MK-591, Free acid DataSheet

Alternate Name/Synonyms: 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid; L686,708; L686,708; L-686,708; MK591; Quiflapon; MK 591

Appearance: Crystalline solid

Formulation:

CAS Number: 136668-42-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₄H₃₅ClN₂O₃S

Molecular Weight: 587.17

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >40 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent 5-Lipoxygenase-activating protein (FLAP) inhibitor

MDL Number:

PubChem CID: 60923

SMILES: CC(C)(C)SC1=C(N(C2=C1C=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)CC5=CC=C(C=C5)Cl)CC(C)(C)C(=O)O

InChi: InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39)

InChi Key: NZOONKHCNQFYCI-UHFFFAOYSA-N