ML-193 | B3016

ML-193 is a selective quinoline aryl sulfonamide antagonist for GPR55, a lysophosphatidylinositol (LPI)-sensitive receptor that is also involved in cannabinoid signaling. It inhibits GPR55 with an IC₅₀ of 221 nM. It also inhibits GPR55-dependent ERK phosphorylation with an IC₅₀ of 65 nM and blocks translocation of PKC βII. Pretreatment with ML-193 (1 μg/0.5 μl, 15 min before LPI), antagonized the LPI-induced nociception in a rat model.

ML-193 is a selective quinoline aryl sulfonamide antagonist for GPR55, a lysophosphatidylinositol (LPI)-sensitive receptor that is also involved in cannabinoid signaling. It inhibits GPR55 with an IC₅₀ of 221 nM. It also inhibits GPR55-dependent ERK phosphorylation with an IC₅₀ of 65 nM and blocks translocation of PKC βII. Pretreatment with ML-193 (1 μg/0.5 μl, 15 min before LPI), antagonized the LPI-induced nociception in a rat model.

B3016 | ML-193 DataSheet

Alternate Name/Synonyms: N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-6,8-dimethyl-2-pyridin-2-ylquinoline-4-carboxamide; N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide; N-[4-[(3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridyl)cinchoninamide; CID-1261822

Appearance: White solid

Formulation:

CAS Number: 713121-80-3

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₈H₂₅N₅O₄S

Molecular Weight: 527.6

Cell-Permeable?: TRUE

Purity: 0.98

Solubilities: 2 mg/ml in DMSO, 3 mg/ml in DMF, 0.1 mg/ml in Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective antagonist for GPR55

MDL Number: MFCD05999971

PubChem CID: 1261822

SMILES: CC1=CC(=C2C(=C1)C(=CC(=N2)C3=CC=CC=N3)C(=O)NC4=CC=C(C=C4)S(=O)(=O)NC5=C(C(=NO5)C)C)C

InChi: InChI=1S/C28H25N5O4S/c1-16-13-17(2)26-22(14-16)23(15-25(31-26)24-7-5-6-12-29-24)27(34)30-20-8-10-21(11-9-20)38(35,36)33-28-18(3)19(4)32-37-28/h5-15,33H,1-4H3,(H,30,34)

InChi Key: HTSLEZOTMYUPLU-UHFFFAOYSA-N