ML-216 | B2666

ML-216 is a potent and selective inhibitor of BLM (Bloom) helicase (IC₅₀ = 1.8 μM); it displays 28-fold selectivity against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.

ML-216 is a potent and selective inhibitor of BLM (Bloom) helicase (IC₅₀ = 1.8 μM); it displays 28-fold selectivity against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.

B2666 | ML-216 DataSheet

Alternate Name/Synonyms: N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]-urea; CID-49852229

Appearance: Light orange to dark orange solid

Formulation:

CAS Number: 1430213-30-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₉F₄N₅OS

Molecular Weight: 383.3

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A BLM helicase inhibitor

MDL Number:

PubChem CID: 49852229

SMILES: FC1=CC=C(NC(NC2=NN=C(C3=CC=NC=C3)S2)=O)C=C1C(F)(F)F

InChi: InChI=1S/C15H9F4N5OS/c16-11-2-1-9(7-10(11)15(17,18)19)21-13(25)22-14-24-23-12(26-14)8-3-5-20-6-4-8/h1-7H,(H2,21,22,24,25)

InChi Key: WMCOYUSJXXCHFH-UHFFFAOYSA-N