Description
ML-216 is a potent and selective inhibitor of BLM (Bloom) helicase (IC₅₀ = 1.8 μM); it displays 28-fold selectivity against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.
ML-216 is a potent and selective inhibitor of BLM (Bloom) helicase (IC₅₀ = 1.8 μM); it displays 28-fold selectivity against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.
Alternate Name/Synonyms: N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]-urea; CID-49852229
Appearance: Light orange to dark orange solid
Formulation:
CAS Number: 1430213-30-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₉F₄N₅OS
Molecular Weight: 383.3
Cell-Permeable?: True
Purity: ≥98%
Solubilities: >20 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A BLM helicase inhibitor
MDL Number:
PubChem CID: 49852229
SMILES: FC1=CC=C(NC(NC2=NN=C(C3=CC=NC=C3)S2)=O)C=C1C(F)(F)F
InChi: InChI=1S/C15H9F4N5OS/c16-11-2-1-9(7-10(11)15(17,18)19)21-13(25)22-14-24-23-12(26-14)8-3-5-20-6-4-8/h1-7H,(H2,21,22,24,25)
InChi Key: WMCOYUSJXXCHFH-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |