Description
ML-277 is a potent activator of KCNQ1 (Kv7.1) channels (EC₅₀ = 260nM). It displays >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential.
ML-277 is a potent activator of KCNQ1 (Kv7.1) channels (EC₅₀ = 260nM). It displays >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential.
Alternate Name/Synonyms: VU0458298-2,(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide,ML277,CID-53347902
Appearance: Crystalline solid
Formulation:
CAS Number: 1401242-74-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₅N₃O₄S₂
Molecular Weight: 471.59
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent activator of KCNQ1 (Kv7.1) channels
MDL Number:
PubChem CID: 53347902
SMILES: O=C([C@@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3
InChi: InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
InChi Key: OXQNLLVUVDAEHC-OAQYLSRUSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |