Description
ML323 is a potent, reversible, inhibitor of USP1-UAF1 with IC₅₀ of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.
ML323 is a potent, reversible, inhibitor of USP1-UAF1 with IC₅₀ of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.
Alternate Name/Synonyms: 4-Pyrimidinamine, 5-methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1572414-83-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₄N₆
Molecular Weight: 384.48
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>50 mg/ml) or EtOH (>25 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A USP1-UAF1 inhibitor
MDL Number: N/A
PubChem CID: 60167849
SMILES: CC1=CN=C(N=C1NCC2=CC=C(C=C2)N3C=CN=N3)C4=CC=CC=C4C(C)C
InChi: nChI=1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
InChi Key: VUIRVWPJNKZOSS-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |