ML-324 | 2763

Cell-permeable. ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC₅₀ = 920 nM). Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC₅₀ ~ 10 µM) and abrogates infection. Represses the reactivation of HSV from the latent state in sensory neurons.

ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC₅₀ = 920 nM). Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC₅₀ ~ 10 µM) and abrogates infection. Represses the reactivation of HSV from the latent state in sensory neurons.

2763 | ML-324 DataSheet

Alternate Name/Synonyms: N-(3-(dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide

Appearance: Light brown solid

Formulation: N/A

CAS Number: 1222800-79-4

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₃N₃O₂

Molecular Weight: 349.43

Cell-Permeable?: Y

Purity: ≥98% by TLC

Solubilities: DMSO (~ 20 mg/ml, warm) or EtOH (~ 6 mg/ml, warm)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: AJMJD2 histone demethylase inhibitor

MDL Number: MFCD28053518

PubChem CID: N/A

SMILES: OC1=CC(C2=CC=C(C(NCCCN(C)C)=O)C=C2)=CC3=CC=CN=C31

InChi: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)

InChi Key: QDBVSOZTVKXUES-UHFFFAOYSA-N