ML-385 | B2605

ML-385 is a potent and selective Nrf2 inhibitor (Nrf2; IC₅₀ = 1.9 µM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.

ML-385 is a potent and selective Nrf2 inhibitor (Nrf2; IC₅₀ = 1.9 µM). ML-385 blocks Nrf2 d

B2605 | ML-385 DataSheet

Alternate Name/Synonyms: ML385, N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide

Appearance: White solid

Formulation:

CAS Number: 846557-71-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₂₅N₃O₄S

Molecular Weight: 511.59

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >25 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective NRF2 inhibitor

MDL Number:

PubChem CID: 1383822

SMILES: CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C

InChi: InChI=1S/C29H25N3O4S/c1-17-5-3-4-6-22(17)28(34)32-12-11-20-15-21(8-9-23(20)32)27-18(2)37-29(31-27)30-26(33)14-19-7-10-24-25(13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3,(H,30,31,33)

InChi Key: LINHYWKZVCNAMQ-UHFFFAOYSA-N