Description
Cell-permeable. A potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPase (IC₅₀ = 2.6 and 5.4 μM for Cdc42 wild type and activated mutant, respectively). No appreciable inhibitory activity up to 100 μM was observed with Rac1, Rab2, Rab7 or Ras in the multiplex screen.
ML141 is a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPase (IC₅₀ = 2.6 and 5.4 μM for Cdc42 wild type and activated mutant, respectively).
Alternate Name/Synonyms: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide’; CID2950007
Appearance: Off-white solid
Formulation: N/A
CAS Number: 71203-35-5
Structure Available?: Yes
Peptide sequence: No
Salt Form: No
Molecular Formula: C₂₂H₂₁N₃O₃S
Molecular Weight: 407.49
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~30 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A Cdc42 GTPase inhibitor
MDL Number: MFCD05987165
PubChem CID: 2950007
SMILES: COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C4=CC=CC=C4
InChi: InChI=1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)
InChi Key: QBNZBMVRFYREHK-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |