ML141 | 2267

Cell-permeable. A potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPase (IC₅₀ = 2.6 and 5.4 μM for Cdc42 wild type and activated mutant, respectively). No appreciable inhibitory activity up to 100 μM was observed with Rac1, Rab2, Rab7 or Ras in the multiplex screen.

ML141 is a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPase (IC₅₀ = 2.6 and 5.4 μM for Cdc42 wild type and activated mutant, respectively).

2267 | ML141 DataSheet

Alternate Name/Synonyms: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-­3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide’; CID2950007

Appearance: Off-white solid

Formulation: N/A

CAS Number: 71203-35-5

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₂H₂₁N₃O₃S

Molecular Weight: 407.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~30 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A Cdc42 GTPase inhibitor

MDL Number: MFCD05987165

PubChem CID: 2950007

SMILES: COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C4=CC=CC=C4

InChi: InChI=1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)

InChi Key: QBNZBMVRFYREHK-UHFFFAOYSA-N