MMP-13, Catalytic Domain, Human Recombinant | P1230

MMP-13 is a member of the matrix metalloproteinase (MMP) family of enzymes. MMP enzymes are associated with remodeling and breaking down matrix proteins. Aberrant expressions of different MMP enzymes have been associated with periodontal disease, arthritis and caner metastasis. MMP-13 has been associated with breast cancer. This constitutively active MMP-13 lacks the inhibitory pro-domain and hemopexin domain.

P1230 | MMP-13 Catalytic Domain Human Recombinant DataSheet

Biomolecule/Target: MMP-13

Synonyms: Collagenase 3, Matrix metalloproteinase, CLN-3

Alternates names: Collagenase 3, Matrix metalloproteinase, CLN-3

Taglines: A Protein involved in breakdown of extracellular matrix

NCBI Gene ID #: 20302

NCBI Gene Symbol: CCL3

Gene Source: Human

Accession #: P10855

Recombinant: Yes

Source: E.coli

Purity by SDS-PAGEs: 99%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): Measured by its ability to hydrolyze 1.0 umole of MMP-13 substrate per minute at pH 7.5 and 37ºC.

Biological activity: Determined by its ability to chemoattract Balb/c peripheral blood MNCs and mouse Balb/c splenocytes using a concentration range of 10-100 ng/ml.

Results: 200 mU/mg

Binding Capacity: N/A

Unit Definition: One unit is the amount of enzyme that will hydrolyze 1.0 umole of MMP-13 substrate per minute at pH 7.5 and 37ºC.

Molecular Weight: 20.5 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Proprietary Buffer

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1 mg/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A