MMP2 Antibody| F43169-0.08ML/F43169-0.4ML/F53512-0.1ML/R32672/RQ5212/V3247-20UG

MMP2 Antibody| F43169-0.08ML/F43169-0.4ML/F53512-0.1ML/R32672/RQ5212/V3247-20UG | Gentaur UK, US & Europe Distribution

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Rat, Chicken, Rabbit

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the MMP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This MMP2 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 303-331 from the human protein was used as the immunogen for this MMP2 antibody.

Storage: Aliquot the MMP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A