MMRN1 polyclonal Antibody | BS8331

MMRN1 polyclonal Antibody | BS8331 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep

Application: ELISA

Application Range: ELISA：1:5000-1:10000

Background: Multimerin-1 is a 1,228 amino acid secreted protein that contains one C1q domain, one EMI domain and one EGF-like domain. Synthesized in megakaryocytes and endothelial cells and present in liver, lung and placenta, Multimerin-1 exists as a multimeric structure composed of varying disulfide-linked multimers and functions as a carrier protein for platelet factors (specifically platelet factor V), playing a role in the stabilization and storage of factor V in platelets. In addition, Multimerin-1 acts as a ligand for select Integrins and may participate in extracellular matrix adhesion. Defects in the gene encoding Multimerin-1 that lead to Multimerin-1 deficiency are associated with autosomal dominant bleeding disorders due to platelet factor malfunction. Multiple isoforms of Multimerin-1 exist due to alternative splicing events.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MMRN1 polyclonal Antibody detects endogenous levels of MMRN1 protein.

Molecular Weight: ~ 136 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ECM; Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; EMILIN 4; EMILIN4; Endothelial cell multimerin 1; Glycoprotein Ia; GlycoproteinIa; GPIa; MMRN 1; MMRN; Multimerin 1; Multimerin-1; Multimerin1; MMRN1_HUMAN.

Immunogen: KLH conjugated synthetic peptide derived from human MMRN1:851-950/1228 

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Inhibition of Apoptosis