MN64 | B1127

MN64 is a potent and selective tankyrase (TNKS) inhibitor (IC₅₀ values of 6 and 72 nM for TNKS1 and TNKS2 respectively). It has no effect on PARP-1 or PARP-2 (IC₅₀ > 19 µM). Through its effects on TNKS, MN-64 inhibits signaling along the Wnt/β-catenin pathway in a cell-based reporter assay.

MN64 is a potent and selective tankyrase (TNKS) inhibitor (IC₅₀ values of 6 and 72 nM for TNKS1 and TNKS2 respectively). It has no effect on PARP-1 or PARP-2 (IC₅₀ > 19 µM). Through its effects on TNKS, MN-64 inhibits signaling along the Wnt/β-catenin pathway in a cell-based reporter assay.

B1127 | MN64 DataSheet

Alternate Name/Synonyms: 2-[4-(1-methylethyl)phenyl]-4H-1-benzopyran-4-one

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 92831-11-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₆O₂

Molecular Weight: 264.32

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml) or EtOH (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective tankyrase (TNKS) inhibitor

MDL Number: MFCD00829158

PubChem CID: 2802462

SMILES: CC(C)C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2

InChi: InChI=1S/C18H16O2/c1-12(2)13-7-9-14(10-8-13)18-11-16(19)15-5-3-4-6-17(15)20-18/h3-12H,1-2H3

InChi Key: PYTOHIUBXSJKQH-UHFFFAOYSA-N