26
Moexipril hydrochloride | B2134
- SKU:
- 26-B2134-GEN
- Availability:
- Usually shipped in 5 working days
Description
Moexipril is a prodrug of the long-acting angiotensin converting enzyme (ACE) inhibitor moexiprilat (IC₅₀s = 2.1 nM and 2.7 µM for moexiprilat and moexipril, respectively). In addition to its antihypertensive activity, moexipril has been identified as a phosphodiesterase 4 inhibitor (IC₅₀ = 38 µM for the PDE4B2 isoform) that increases cAMP in cells.
Moexipril is a prodrug of the long-acting angiotensin converting enzyme (ACE) inhibitor moexiprilat (IC₅₀s = 2.1 nM and 2.7 µM for moexiprilat and moexipril, respectively). In addition to its antihypertensive activity, moexipril has been identified as a phosphodiesterase 4 inhibitor (IC₅₀ = 38 µM for the PDE4B2 isoform) that increases cAMP in cells.
B2134 | Moexipril hydrochloride DataSheet
Alternate Name/Synonyms: (3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid hydrochloride
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 82586-52-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₃₅N₂O₇Cl
Molecular Weight: 535.03
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: H₂O (30 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A potent angiotensin converting-Enzyme (ACE) inhibitor
MDL Number: MFCD00940481
PubChem CID: 54889
SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC(=C(C=C3CC2C(=O)O)OC)OC.Cl
InChi: InChI=1S/C27H34N2O7.ClH/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32;/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32);1H/t17-,21-,22-;/m0./s1
InChi Key: JXRAXHBVZQZSIC-JKVLGAQCSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |