Monastrol | B2269

Monastrol is a potent, cell-permeable, small molecule mitosis inhibitor. It arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC₅₀ = 14 μM).

Monastrol is a potent, cell-permeable, small molecule mitosis inhibitor. It arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC₅₀ = 14 μM).

B2269 | Monastrol DataSheet

Alternate Name/Synonyms: 1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester

Appearance: White solid

Formulation: N/A

CAS Number: 254753-54-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₆N₂O₃S

Molecular Weight: 292.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml) or EtOH (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, cell-permeable, small molecule mitosis inhibitor

MDL Number: MFCD00813077

PubChem CID: 2987927

SMILES: CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C

InChi: InChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)

InChi Key: LOBCDGHHHHGHFA-UHFFFAOYSA-N