Monoclonal Antibodies to TIMP1 | NBP0226

Monoclonal Antibodies to TIMP1 | NBP0226 | Gentaur UK, US & Europe Distribution

Host: mouse

Expression: N/A

Tag: N/A

Isotype: IgG1 kappa

Determination Method: immunochromatography or chemiluminescent immunoassay

Application: N/A

General Information: TIMPs are members of the family of tissue inhibitor of matrix metalloproteinases (MMPs) that includes TIMP1, TIMP2, TIMP3, and TIMP4. The main function of TIMPs is their inhibitory effect on MMPs. TIMPs irreversibly inactivate MMPs by direct binding to their catalytic zinc cofactor and resultant inhibition of proteinase function. In addition to MMP inhibition, TIMPs have also been shown to interact with various membrane receptors on the cell surface. Some of these interactions include: TIMP1 with CD63, TIMP2 with α3β1 integrin, and TIMP3 with VEGFR2, all of which result in distinct cellular effects. TIMPs are involved in a wide variety of biological functions, such as tumor angiogenesis and progression, wound healing, and vascular remodeling. Mutations in TIMP3 are associated with Sorsby's fundus dystrophy.

Recomendation: N/A

Product Buffer: PBS, pH7.4.

Purity: >95% as determined by SDS-PAGE.

Storage: Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.

Specificity: Recognizes native TIMP1

Source: N/A

Molecular weight: N/A

Note: N/A