Motesanib | 2022

Cell-permeable. Motesanib, also known as AMG-706, is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC₅₀ values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit). It also potently inhibits angiogenesis and induces regression in tumor xenografts.

Motesanib, also known as AMG-706, is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC₅₀ values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit).

2022 | Motesanib DataSheet

Alternate Name/Synonyms: AMG-706

Appearance: White solid

Formulation: N/A

CAS Number: 453562-69-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₃N₅O

Molecular Weight: 373.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (200 mg/ml) or EtOH (40 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent multikinase inhibitor selective to VEGFRs and PDGFrs

MDL Number: MFCD10567689

PubChem CID: 11667893

SMILES: CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C

InChi: InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3- 9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H, 27,28)

InChi Key: RAHBGWKEPAQNFF-UHFFFAOYSA-N