Mouse Anti-Human ACE Antibody | 101-M200

Mouse Anti-Human ACE Antibody | 101-M200 | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Mouse

Comment: N/A

Label: N/A

Clone / Antibody feature: (#12J16)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: Angiotensin I converting enzyme; CD143; testicular ECA carboxycathepsin; DCP; ACE1; DCP1; MVCD3;

Isotype: IgG1

Application: WB

Detection Range: WB: 1:500-1000.

Species Reactivity/Cross reactivity: Human

Antigen: Human ACE recombinant protein (extracellular domain)

Description: Angiotensin I Converting Enzyme (ACE, also known as peptidyl-dipeptidase A, kininase II, or CD143) is a type I transmembrane zinc metallopeptidase that is important in the metabolism of the vaso-active peptides angiotensin II and bradykinin. Two isoforms of ACE that exhibit distinct physiologic functions have been described: germinally expressed ACE (gACE) and somatic cell expressed ACE (sACE). Both isoforms are transcribed from a single gene using alternative promoters. The gACE isoform is exclusively expressed in the testes, whereas sACE is expressed on endothelial cells, epithelial cells, neuronal cells, and dendritic cells. A soluble form of CD143 is likely shed from endothelial cells and is found in serum, plasma, seminal fluid, amniotic fluid and cerebral spinal fluid. Functionally, CD143 has a role in blood pressure regulation, electrolyte balance, reproduction, cardiovascular disease, kidney disease, cancer and Alzheimer’s disease. Inhibitors of ACE are used clinically to treat hypertension, cardiac failure, and diabetic retinopathy.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 1636