Mouse Anti-Human BMP receptor-2 Antibody | 101-M177

Mouse Anti-Human BMP receptor-2 Antibody | 101-M177 | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Mouse

Comment: N/A

Label: N/A

Clone / Antibody feature: (#9A10)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: BMPR2; BMR2; PPH1; BMPR3; BRK-3; T-ALK; BMPR-II

Isotype: IgG1

Application: WB

Detection Range: N/A

Species Reactivity/Cross reactivity: Human

Antigen: recombinant human BMP RII extra cellular domain

Description: Like other members of the TGFβ superfamily, cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the binding to heteromeric complex of type I and type II serine-threonine kinase receptors. Both receptor types are required for the signl transduction. BMP receptor II (BMPR II or BMPR-2) is one of the five mammalian type II receptors (including TGFβRII, ActRII, ActRIIB, BMPRII and MISRII) for the TGFβ superfamily ligands. The type II receptors for TGFβ and activin bind ligands with high affinity by itself. In contrast, BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor. BMPRII mRNA is widely expressed in fetal and adult tissues. Human and mouse BMPRII are highly conserved sharing 97% sequence identity.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 659