Mouse Anti-Human FAS Antibody | 101-M134

Mouse Anti-Human FAS Antibody | 101-M134 | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Mouse

Comment: N/A

Label: N/A

Clone / Antibody feature: (#12J3)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: FAS; APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6

Isotype: IgG1

Application: WB, IHC (P)

Detection Range: N/A

Species Reactivity/Cross reactivity: Human

Antigen: recombinant human FAS

Description: Fas, also known as APO1, CD95, and TNFRSF6, was originally identified as a cellsurface protein which binds to monoclonal antibodies that were cytolytic for various human cell lines. In the new TNF Receptor superfamily nomenclature, Fas is referred to as TNFRSF6. Human Fas cDNA encodes a 325 amino acid (aa) residue type 1 membrane protein that belongs to the TNF and NGF receptor family. Alternatively spliced cDNAs encoding multiple Fas isoforms, including a soluble form of Fas lacking the transmembrane domain, have also been identified. Fas is highly expressed in epithelial cells, hepatocytes, activated mature lymphocytes, virus-transformed lymphocytes, and other tumor cells. Fas expression has also been detected in mouse thymus, liver, heart, lung, kidney and ovary. The ligand for Fas (FasL) has been identified and shown to be a member of the TNF family of type 2 membrane proteins. Fas-L is predominantly expressed by activated Tlymphocytes, NK cells, and in tissues with immuneprivileged sites. Soluble Fas-L can be produced by proteolysis of membrane-associated Fas.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 355