Mouse Anti-Human FGF-6 Antibody | 101-M411

Mouse Anti-Human FGF-6 Antibody | 101-M411 | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Mouse

Comment: N/A

Label: N/A

Clone / Antibody feature: (#8N21)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: FGF6; HST2; HBGF-6

Isotype: IgG1

Application: WB, N

Detection Range: N/A

Species Reactivity/Cross reactivity: Human

Antigen: Recombinant human FGF-6

Description: Fibroblast Growth Factor-6 (FGF-6), also known as HST2, is a 25-28 kDa member of the FGF family of heparin binding polypeptides which are potent regulators of cell proliferation, differentiation, and function. FGF proteins contain a 120 amino acid (aa) core FGF domain that exhibits a β-trefoil structure. Mature human FGF6 is a 171 aa protein that shares 94% aa sequence identity with mouse and rat FGF6. It binds and signals primarily through FGF R1c, 2c, and 4. FGF6 functions as a mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells, and N-linked glycosylation is required for the full mitogenic effect. FGF6 expression is restricted to skeletal muscle during development although it can be upregulated in prostate cancer and Kaposi sarcoma. In the adult, FGF6 is upregulated in injured skeletal muscle and is required for muscle regeneration. FGF6 inhibits the terminal differentiation of myoblasts and also cooperates with TGFβ-2 to promote chondrogenesis in embryonic somites.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 2251