Mouse Anti-Human IL-20 receptor alpha Antibody | 101-M504

Mouse Anti-Human IL-20 receptor alpha Antibody | 101-M504 | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Mouse

Comment: N/A

Label: N/A

Clone / Antibody feature: (#9F40)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: IL20RA; IL-20R1; ZCYTOR7

Isotype: IgG1

Application: WB, IHC (P)

Detection Range: N/A

Species Reactivity/Cross reactivity: Human

Antigen: recombinant human IL-20 Ralpha EC domain

Description: IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland. The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells. IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals. IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26. Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 53832