Mouse Anti-Human MMP-15 Antibody | 101-M117

Mouse Anti-Human MMP-15 Antibody | 101-M117 | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Mouse

Comment: N/A

Label: N/A

Clone / Antibody feature: (#5D11)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: MMP15; MTMMP2; SMCP-2; MT2-MMP

Isotype: IgG1

Application: WB, IHC (P)

Detection Range: WB: Use at 1:400-1000; IHC: 1:50-200

Species Reactivity/Cross reactivity: Human

Antigen: recombinant human MMP-15

Description: Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. They play critical roles in tissue remodeling, angiogenesis, tumor invasion, and rheumatoid arthritis. MMP15, also known as MT2MMP, is a membranetype MMP that is expressed in many tumor tissues including urothelial carcinoma, oral cancer, ovarian carcinoma, melanoma, and astrocytoma. Structurally, MMP15 consists of the following domains:a pro domain containing a furin cleavage site, a catalytic domain containing the zinc-binding site, a hinge region, a hemopexinlike domain, a transmembrane domain, and a cytoplasmic tail. Recombinant Human (rh) MMP15, consists of the pro domain, catalytic domain, hinge region and hemopexin-like domain. The pro domain contains the mutations R128P and R129G, which prevent activation by furin cleavage. Activation of rhMMP15 is possible by treatment with rhTrypsin.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 4324