Mouse Anti-Human TIE-2-PE Antibody | 101-M54-PE/101-M54S-PE

Mouse Anti-Human TIE-2-PE Antibody | 101-M54-PE/101-M54S-PE | Gentaur UK, US & Europe Distribution

Species: Anti-Human

Host / biotech: Mouse

Comment: N/A

Label: PE

Clone / Antibody feature: (#tek16)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: TEK; TIE2; VMCM; TIE-2; VMCM1; CD202B; FITC

Isotype: IgG1

Application: FC

Detection Range: FACS analysis: Use at 2-5 µg/ml.

Species Reactivity/Cross reactivity: Human

Antigen: recombinant human soluble extracellular TIE-3

Description: Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: liquid

Storage Handling Stability: Store protected from light at 2-8°C. Do not freeze!

Reconstituation: N/A

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 7010