Mouse Anti-Mouse VEGFR-3/FLT-4, Antagonistic Antibody | mV1003m-m

Mouse Anti-Mouse VEGFR-3/FLT-4, Antagonistic Antibody | mV1003m-m | Gentaur UK, US & Europe Distribution

Species: Anti-Mouse

Host / biotech: Mouse

Comment: N/A

Label: N/A

Clone / Antibody feature: (#9G03)

Subcategory: Monoclonal Antibody

Category: Antibody

Synonyms: vascular endothelial growth factor receptor-3; Flt4; Chy; Flt-4; VEGFR3; VEGFR-3;

Isotype: IgG1

Application: Blocking VEGF-C induced activiation

Detection Range: N/A

Species Reactivity/Cross reactivity: Mouse

Antigen: recombinant mouse VEGFR3 N-terminal protein

Description: VEGFR-3, also known as FLT4, is a member of the Tyr protein kinase family. The extracellular portion of VEGFR-3 contains 7 immunoglobulin (Ig)-like domains and the cytoplasmic portion contains a protein kinase domain. FLT4 regulates angiogenesis and lymphangiogenesis, its ligands are VEGF-C and D and its binding is mediated by the 2nd and 3rd Ig-like domains of FLT4. During fetal development VEGFR-3 is expressed on endothelial cells, however, in the adult mice, the vascular endothelial cells lose VEGFR-3 expression, but the lymphatic endothelium expresses it constitutively. In addition, VEGFR-3 expression can be induced in tumors with active angiogenesis.

Purity Confirmation: N/A

Endotoxin: N/A

Formulation: lyophilized

Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 400 µl sterile PBS and the final concentration is 500 µg/ml.

Molecular Weight: N/A

Lenght (aa): N/A

Protein Sequence: N/A

NCBI Gene ID: 14257