(Mouse) Bmi1 Antibody (Center) [APR33205G]

(Mouse) Bmi1 Antibody (Center) [APR33205G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Bmi1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 109-143 amino acids from the Central region of Mouse Bmi1.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P35226}. Cytoplasm {ECO:0000250|UniProtKB:P35226}

Molecular Weight: 36708

Clone: Polyclonal

Gene Name: Bmi1

Gene ID: 12151

Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity) .

Summary: Tissue Location: Detected in most organs with high expression levels in thymus, heart, brain and testis

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, Bmi1, Bmi-1, Pcgf4