Mouse Dyrk1b Antibody (Center) [APR03984G]

Mouse Dyrk1b Antibody (Center) [APR03984G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Dyrk1b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-403 amino acids from the Central region of mouse Dyrk1b.

Cellular Localisation: Nucleus.

Molecular Weight: 69178

Clone: Polyclonal

Gene Name: Dyrk1b

Gene ID: 13549

Function: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1) .

Summary: Tissue Location: Isoform 1 and isoform 2 are broadly expressed. Isoform 3 seems specific for skeletal muscle (at protein level)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Dyrk1b