Mouse Epc1 Antibody (Center) [APR33009G]

Mouse Epc1 Antibody (Center) [APR33009G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Epc1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 425-460 amino acids from the Central region of Mouse Epc1.

Cellular Localisation: Nucleus.

Molecular Weight: 90411

Clone: Polyclonal

Gene Name: Epc1

Gene ID: 13831

Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity) .

Summary: Tissue Location: Expressed in adult brain, heart, kidney, liver, lung, skeletal muscle and testis.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Enhancer of polycomb homolog 1, Epc1