Mouse Ephb3 Antibody (Center) [APR04749G]

Mouse Ephb3 Antibody (Center) [APR04749G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This Mouse Ephb3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 350-382 amino acids from the Central region of Mouse Ephb3.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite

Molecular Weight: 109662

Clone: Polyclonal

Gene Name: Ephb3

Gene ID: 13845

Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.

Summary: Tissue Location: Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk. Expressed by Paneth and progenitor cells in the crypts of the intestinal epithelium (at protein level) . Expressed in myogenic progenitor cells (PubMed:27446912) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:500-1:1000

Synonyms: Ephrin type-B receptor 3, Developmental kinase 5, mDK-5, Tyrosine-protein kinase receptor SEK-4, Ephb3, Etk2, Mdk5, Sek4