Mouse Hes1 Antibody (C-term) [AMM06440G]

Mouse Hes1 Antibody (C-term) [AMM06440G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Hes1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 205-239 amino acids from the C-terminal region of Mouse Hes1.

Cellular Localisation: Nucleus.

Molecular Weight: 29749

Clone: Polyclonal

Gene Name: Hes1

Gene ID: 15205

Function: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity) . Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity) .

Summary: Tissue Location: Expressed at high levels in undifferentiated neural precursor cells, but the level of expression decreases as neural differentiation proceeds

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:500

Synonyms: Transcription factor HES-1, Hairy and enhancer of split 1, Hes1, Hes-1