Mouse Il17ra Antibody (C-term) [APR31712G]

Mouse Il17ra Antibody (C-term) [APR31712G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Il17ra antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 721-747 amino acids of mouse Il17ra.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein

Molecular Weight: 97808

Clone: Polyclonal

Gene Name: Il17ra

Gene ID: 16172

Function: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:20554964, PubMed:8777726, PubMed:27923703) . Receptor for IL17F (PubMed:17911633, PubMed:20554964) . Binds to IL17A with higher affinity than to IL17F (PubMed:17911633) . Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity) . Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity) . Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (By similarity) . Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (PubMed:21993848, PubMed:20364087) . In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (PubMed:18157131) . Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317) . Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity (PubMed:27795421) . Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (PubMed:26735852) . Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848, PubMed:21993849, PubMed:21982598) .

Summary: Tissue Location: Widely expressed (PubMed:21993848) . Highly expressed in T cells and macrophages (PubMed:19144317) . Highly expressed in B-1a B cells and at a lower extent in B-1b and B-2 B cells (at protein level) (PubMed:26735852) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CD217, Il17ra, Il17r