Mouse Jarid2 Antibody (Center) [AMM06445G]

Mouse Jarid2 Antibody (Center) [AMM06445G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Jarid2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the Central region of Mouse Jarid2.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:10807864, ECO:0000269|PubMed:10913339, ECO:0000269|PubMed:20064375, ECO:0000269|PubMed:20064376}. Note=Colocalizes with the PRC2 complex on chromatin

Molecular Weight: 137445

Clone: Polyclonal

Gene Name: Jarid2

Gene ID: 16468

Function: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:10807864, PubMed:12852854, PubMed:12890668, PubMed:15542826, PubMed:15870077, PubMed:19010785, PubMed:20064375, PubMed:20064376, PubMed:20075857) . Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20064376, PubMed:20064375) . Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20064375, PubMed:20075857) . In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (PubMed:12852854, PubMed:12890668, PubMed:19010785) . Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (PubMed:15542826) . Participates in the negative regulation of cell proliferation signaling (PubMed:10913339) . Does not have histone demethylase activity (PubMed:20064376) .

Summary: Tissue Location: Widely expressed in embryos. In adults, expressed at high levels in heart, skeletal muscle, brain and thymus

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Protein Jumonji, Jumonji/ARID domain-containing protein 2, Jarid2, Jmj