LBD
Mouse Kdm6a Antibody (C-term) [APR33061G]
- SKU:
- LBD-APR33061G
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Description
Mouse Kdm6a Antibody (C-term) [APR33061G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M
Specificity: This mouse Kdm6a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1041-1074 amino acids from the C-terminal region of mouse Kdm6a.
Cellular Localisation: Nucleus.
Molecular Weight: 154355
Clone: Polyclonal
Gene Name: Kdm6a
Gene ID: 22289
Function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity) . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (PubMed:21095589) .
Summary: Tissue Location: Expressed in brain, heart and spleen.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Lysine-specific demethylase 6A, 11411-, Histone demethylase UTX, Ubiquitously transcribed TPR protein on the X chromosome, Ubiquitously transcribed X chromosome tetratricopeptide repeat protein, Kdm6a, Utx