Mouse Lmtk3 Antibody (Center) [APR33314G]

Mouse Lmtk3 Antibody (Center) [APR33314G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Lmtk3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 871-905 amino acids from the Central region of Mouse Lmtk3.

Cellular Localisation: Membrane; Single- pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections

Molecular Weight: 150891

Clone: Polyclonal

Gene Name: Lmtk3

Gene ID: 381983

Function: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity) . Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (PubMed:24760852) .

Summary: Tissue Location: Expressed in brain. Predominantly expressed in cerebral cortex, thalamus, the cerebellum and hippocampal formation (at protein level) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Serine/threonine-protein kinase LMTK3, Apoptosis-associated tyrosine kinase 3, Lemur tyrosine kinase 3, Lmtk3, Aatyk3