Mouse Mavs Antibody (N-term) [APR17432G]

Mouse Mavs Antibody (N-term) [APR17432G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Mavs antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of mouse Mavs.

Cellular Localisation: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q7Z434}. Mitochondrion {ECO:0000250|UniProtKB:Q7Z434}. Peroxisome {ECO:0000250|UniProtKB:Q7Z434}

Molecular Weight: 53399

Clone: Polyclonal

Gene Name: Mavs {ECO:0000312|MGI:MGI:2444773}

Gene ID: 228607

Function: Required for innate immune defense against viruses (PubMed:24037184) . Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF- kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) (PubMed:24037184) . Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity) . Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (By similarity) . May activate the same pathways following detection of extracellular dsRNA by TLR3 (By similarity) . May protect cells from apoptosis (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Mitochondrial antiviral-signaling protein, MAVS, CARD adapter inducing interferon beta, Cardif, Interferon beta promoter stimulator protein 1, IPS-1, Virus-induced-signaling adapter, VISA, Mavs, Ips1, Visa