(Mouse) Mlf1 Antibody (Center) [ApR04827G]

(Mouse) Mlf1 Antibody (Center) [ApR04827G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Mlf1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 91-126 amino acids from the Central region of Mouse Mlf1.

Cellular Localisation: Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Shuttles between the cytoplasm and nucleus.

Molecular Weight: 30432

Clone: Polyclonal

Gene Name: Mlf1

Gene ID: 17349

Function: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Summary: Tissue Location: Highly expressed in skeletal muscle, heart, testis. Also found in lung, but not in spleen, thymus, bone marrow, liver and kidney.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:500

Synonyms: Myeloid leukemia factor 1, Hematopoietic lineage switch 7, Myelodysplasia-myeloid leukemia factor 1, Mlf1, Hls7