Mouse Mylk3 Antibody (N-term) [APR17434G]

Mouse Mylk3 Antibody (N-term) [APR17434G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Mylk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-203 amino acids from the N-terminal region of mouse Mylk3.

Cellular Localisation: Cytoplasm.

Molecular Weight: 86372

Clone: Polyclonal

Gene Name: Mylk3

Gene ID: 213435

Function: Kinase that phosphorylates MYL2 in vitro. Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317) . Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility.

Summary: Tissue Location: Restricted to cardiomyocytes (at protein level) . Down-regulated in heart after experimental myocardial infarction at the protein level; no significant changes at the mRNA level

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Myosin light chain kinase 3, Cardiac-MyBP-C-associated Ca/CaM kinase, Cardiac-MLCK, Mylk3