Mouse Nkx2-5 Antibody (Center) [AMM06451G]

Mouse Nkx2-5 Antibody (Center) [AMM06451G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: Ha, M, Rat

Specificity: This Mouse Nkx2-5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 192-225 amino acids from the Central region of human Mouse Nkx2-5.

Cellular Localisation: Nucleus.

Molecular Weight: 34163

Clone: Polyclonal

Gene Name: Nkx2-5

Gene ID: 18091

Function: Transcription factor required for the development of the heart and the spleen (PubMed:9584153, PubMed:19483677, PubMed:22560297) . During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (PubMed:9584153) . May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (PubMed:12023302) . Binds to the core DNA motif of NPPA promoter (PubMed:19483677) . Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297) .

Summary: Tissue Location: Predominantly in the adult and embryonic heart, and to a lesser extent in lingual muscle, spleen and stomach

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Homeobox protein Nkx-25, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Nkx2-5, Csx, Nkx-25, Nkx2e