Mouse Pax6 Antibody (C-term) [AMM06465G]

Mouse Pax6 Antibody (C-term) [AMM06465G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This mouse Pax6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 404-436 amino acids from the C-terminal region of mouse Pax6.

Cellular Localisation: Nucleus. [Isoform 3]: Nucleus. Cytoplasm

Molecular Weight: 46683

Clone: Polyclonal

Gene Name: Pax6

Gene ID: 18508

Function: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (PubMed:9163426) . Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity) . Acts as a transcriptional repressor of NFATC1-mediated gene expression (PubMed:23990468) .

Summary: Tissue Location: Expressed in osteoclasts. [Isoform 3]: Dominant isoform expressed in the eye, including in the retina and cornea (PubMed:21084637) . Weakly expressed in the lens epithelium (PubMed:21084637)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Paired box protein Pax-6, Oculorhombin, Pax6, Pax-6, Sey