Mouse Rcvrn Antibody (N-term) [APR14133G]

Mouse Rcvrn Antibody (N-term) [APR14133G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Rcvrn antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-67 amino acids from the N-terminal region of mouse Rcvrn.

Cellular Localisation: Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (PubMed:15961391) . Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity) {ECO:0000250|UniProtKB:P21457, ECO:0000269|PubMed:15961391}

Molecular Weight: 23407

Clone: Polyclonal

Gene Name: Rcvrn

Gene ID: 19674

Function: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity) . Modulates light sensitivity of cone photoreceptor in dark and dim conditions (PubMed:25673692) . In response to high Ca (2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity) . Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (PubMed:15882641) . Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (PubMed:29435986) .

Summary: Tissue Location: Expressed in rod photoreceptors in the retina (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Recoverin, 23 kDa photoreceptor cell-specific protein, Cancer-associated retinopathy protein, Protein CAR, Rcvrn, Rcv1