Mouse Sash1 Antibody (C-term) [APR31795G]

Mouse Sash1 Antibody (C-term) [APR31795G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Sash1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 870-896 amino acids from the C-terminal region of mouse Sash1.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:O94885}.

Molecular Weight: 135591

Clone: Polyclonal

Gene Name: Sash1

Gene ID: 70097

Function: Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS) -induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.

Summary: Tissue Location: Expressed in the microvascular endothelium of various organs, as well as in parenchymal cells. Expressed in the endothelium but not lymphoid cells of spleen and thymus

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: SAM and SH3 domain-containing protein 1, Sash1